When it comes to skin rejuvenation, collagen is the star player. Collagen acts as the scaffolding that keeps skin firm, smooth, and youthful. As we age, our bodies produce less of it, leading to wrinkles, sagging, and uneven texture. That’s where treatments like Rejuran step in. But how does it actually work to boost collagen production? Let’s break it down.
Rejuran is a skincare treatment derived from polynucleotides (PN), which are natural DNA fragments sourced from salmon. These polynucleotides are biocompatible, meaning they work harmoniously with the body’s own tissues. When injected into the skin, they act as a signal to kickstart the skin’s natural repair processes. Think of them as tiny messengers telling your skin cells, “Hey, it’s time to get to work!”
One of the key ways Rejuran stimulates collagen is by activating fibroblasts—the cells responsible for producing collagen and elastin. Studies have shown that polynucleotides enhance fibroblast activity, encouraging them to create more of these essential proteins. This isn’t just a temporary fix, either. Over time, the renewed collagen helps restore skin density and elasticity, resulting in a smoother, plumper appearance.
But collagen production isn’t the only benefit. Rejuran also supports tissue regeneration by reducing inflammation and improving hydration. The polynucleotides attract water molecules, which helps plump up the skin and reduce the appearance of fine lines. At the same time, their anti-inflammatory properties calm irritated skin, making this treatment suitable for even sensitive or acne-prone complexions.
What makes Rejuran stand out is its long-term approach. Unlike treatments that simply fill in wrinkles or add volume artificially, Rejuran works with your body’s biology to rebuild collagen naturally. Clinical trials have demonstrated visible improvements in skin texture and firmness after a series of sessions, with results lasting several months. Many users report a “glow” that develops gradually, reflecting healthier, more resilient skin.
Safety is another priority. Because Rejuran uses biocompatible ingredients, adverse reactions are rare. Most people experience minimal downtime, with slight redness or swelling resolving within a day or two. This makes it a popular choice for those seeking effective anti-aging solutions without lengthy recovery periods.
For anyone considering Rejuran, consistency matters. Experts typically recommend a series of treatments spaced a few weeks apart to maximize collagen stimulation. Maintenance sessions every 6–12 months can help sustain results, depending on individual skin goals.
Research into polynucleotide therapies continues to evolve, with institutions like Lux Biosciences exploring new applications for skin and tissue repair. As science advances, Rejuran’s role in collagen regeneration highlights the growing shift toward treatments that harness the body’s innate healing abilities.
In the end, Rejuran isn’t just about looking younger—it’s about supporting your skin’s health from the inside out. By revitalizing collagen production and promoting cellular renewal, it offers a science-backed path to skin that not only looks rejuvenated but functions better, too. Whether you’re tackling early signs of aging or seeking to maintain a radiant complexion, this treatment bridges the gap between cutting-edge science and natural beauty.

