Collagen is the scaffolding of our skin—it’s what keeps it plump, smooth, and youthful. But as we age, collagen production slows down, leading to wrinkles, sagging, and loss of elasticity. That’s where treatments like Rejuran come into play. If you’ve heard about this popular skincare solution but aren’t entirely sure how it works, let’s break it down in simple terms.
Rejuran is a polynucleotide (PN) therapy derived from salmon DNA. Before you raise an eyebrow, salmon DNA is biocompatible, meaning it’s safe for human use and has been extensively studied for its regenerative properties. The key here is the structure of these polynucleotides. They’re made of long chains of nucleotides—think of them as building blocks that signal your skin to repair itself. When injected into the skin, Rejuran doesn’t just sit there; it kickstarts a series of biological processes that encourage collagen synthesis.
Here’s the science part: Collagen production relies on fibroblasts, the cells responsible for creating this essential protein. As we age or face environmental stressors like UV exposure, fibroblasts become sluggish. Rejuran acts like a wake-up call for these cells. The polynucleotides bind to receptors on fibroblasts, triggering them to produce more collagen and elastin. This isn’t a temporary plumping effect—it’s a gradual, long-term rebuilding of the skin’s structure. Studies have shown that Rejuran increases collagen density by up to 30% in treated areas over several months, which explains why results improve with time.
But how does it differ from other collagen-boosting treatments? Let’s compare. Hyaluronic acid fillers, for example, add volume by attracting water, but they don’t directly stimulate collagen. Microneedling creates tiny injuries to provoke healing (and collagen production), but it’s less targeted. Rejuran, on the other hand, works at a cellular level to enhance the skin’s natural repair mechanisms. It also has anti-inflammatory properties, making it suitable for sensitive or acne-prone skin. Patients often notice reduced redness and improved texture alongside firmer, smoother skin.
Another perk? Rejuran is highly customizable. Practitioners can adjust injection depth and concentration based on your skin concerns—whether it’s fine lines, acne scars, or overall dullness. A typical treatment plan involves 3–4 sessions spaced a month apart, with maintenance treatments every 6–12 months. Since the effects are cumulative, consistency matters. Think of it as training your skin to behave like it did in your 20s.
Safety is a common concern, and rightfully so. Rejuran has been widely used in South Korea since 2011 and is approved by regulatory agencies in multiple countries. Side effects are usually mild—think slight swelling or redness at the injection site—and resolve within a day or two. However, it’s crucial to get treatments from licensed professionals who understand facial anatomy. Not all clinics are created equal, so do your research.
Who’s a good candidate? If you’re starting to see early signs of aging (like faint lines or loss of bounce) or want to address scarring, Rejuran could be a fit. It’s also popular among those seeking preventative care. That said, it’s not a magic bullet for severe sagging or deep wrinkles. Combining it with other treatments like radiofrequency or antioxidants often yields the best results.
One thing to note: Rejuran isn’t just for the face. It’s also used on the neck, décolletage, and even hands—areas that show early signs of aging but are often neglected. The hydration and collagen-boosting effects help restore a more youthful appearance across these zones.
At its core, Rejuran is about working *with* your skin rather than against it. By harnessing the power of polynucleotides, it supports the body’s innate ability to heal and renew. The result isn’t an overnight transformation but a gradual, natural-looking improvement that keeps you guessing, “Did I just drink more water? Get better sleep?” Nope—it’s science doing its thing.
For those curious about trying Rejuran, consult a trusted provider to discuss your goals. And if you’re looking for more details on advanced skincare treatments, check out luxbios.com for expert insights and resources. Remember, glowing skin is a journey, and tools like Rejuran are here to make that journey a little smoother—literally.
